The advent of the internet has radically changed the job market as well as industrial processes, and the pace of this change is increasing as new technologies develop and both organisations and individuals take them up, adjust them to their needs and scale them. E-commerce has become a key selling channel for both large and small companies worldwide, the sharing economy is already allowing citizens to monetise on both their expertise and their assets, whilst cyber-physical systems, AI, 3D printing, the Internet of things and cloud computing are radically changing production models for traditional industries as diverse as manufacturing, healthcare, energy management, transportation or agriculture. Whilst the potential of the web to foster entrepreneurship and self-entrepreneurship, and to radically improve efficiency, sustainability and competitiveness of both small and large enterprises is clear, several barriers need to be addressed, for instance in terms of interoperability, standardisation and security, both at technological and at legal and fiscal level. Similarly, if we want the “4th industrial revolution” to positively impact on citizens, we need to better understand the consequences of automation and the data economy on employment, as well as the impact of new forms of e-entrepreneurship on social security, so for example, as highlighted in a recent WEF report, 65% of students attending primary school today are likely to work in jobs that don’t yet exist by 2020, and in the meantime up to 7.1 million jobs could be lost, two thirds of which concentrated in routine white collar office functions. In this panel, top scientists, business innovators and policy-makers will look at how new technologies are changing the internet landscape, disrupting markets and industrial processes, and exchange on incentives and barriers to smart and inclusive growth.